Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes
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چکیده
منابع مشابه
Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes.
Detoxification of ingested xenobiotic chemicals, and of potentially toxic endogenous metabolites, is carried out largely through a series of enzymes synthesized in the liver, sometimes called "xenobiotic metabolizing enzymes" (XME). Expression of these XME is sexually dimorphic in rodents and humans, with many of the XME expressed at higher levels in females. This expression pattern is thought ...
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Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver.
The nonsteroidal antiestrogen tamoxifen is widely used in breast cancer treatment and is currently under evaluation as a chemopreventive agent for individuals at high risk of contracting the disease. The effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in F344 rat liver have been investigated. Tamoxifen administration for 7 days produced a dose-dependent ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 2013
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.00304.2013